The Rogers Lab
Lab: Chaparral Hall, CR 5435
Office: Chaparral Hall, CR 5419
Phone: 818-677-6219
Lab: Chaparral Hall, CR 5435
Office: Chaparral Hall, CR 5419
Phone: 818-677-6219
Neural crest cells are a population of stem-like cells that originate in the dorsal neural tube and are able to migrate out of the neural tube to distant sites in the developing embryo where they differentiate into diverse derivatives such as craniofacial bone and cartilage, pigment cells, and the neurons and glia of the peripheral nervous system.
Our lab studies the molecular mechanisms that control the formation of cranial neural crest cells and the process that neural crest cells use to leave the neural tube and separate from each other (the epithelial to mesenchymal transition-EMT). Our lab uses both chicken and axolotl model organisms to study neural crest development. EMT occurs in normal embryonic development during gastrulation and neural crest EMT, but it also occurs in disease states such as tumor transformation and fibrosis.
Our lab studies the molecular mechanisms that control the formation of cranial neural crest cells and the process that neural crest cells use to leave the neural tube and separate from each other (the epithelial to mesenchymal transition-EMT). Our lab uses both chicken and axolotl model organisms to study neural crest development. EMT occurs in normal embryonic development during gastrulation and neural crest EMT, but it also occurs in disease states such as tumor transformation and fibrosis.
